Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

Name: Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)
Brand: Novus Biologicals
SKU: NBP2-76580
Price: 759 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-76580

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Product Specifications
Precision
Recovery
Linearity
Scientific Data
Kit Contents
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Sample Type & Volume Required Per Well

Serum, plasma and other biological fluids (100 uL)

Sensitivity

0.10 ng/mL

Assay Range

0.16 - 10 ng/mL

View all IL-18 BPa ELISA Kits »

Product Specifications

Assay Type

Sandwich-ELISA

Kit Type

ELISA Kit (Colorimetric)

Species

Rat

Specificity

This kit recognizes Rat IL18BP in samples. No significant cross-reactivity or interference between Rat IL18BP and analogues was observed.

Precision

Intra-Assay Precision (Precision within an assay) CV% 4.65%

Inter-Assay Precision (Precision between assays) CV% 4.96%

Recovery for Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

Recovery

84-100%

Linearity

Scientific Data Images for Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

ELISA: Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric) [NBP2-76580] -

ELISA: Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric) [NBP2-76580] - Standard Curve Reference

Kit Contents for Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

Biotinylated Detection Ab Diluent
Concentrated Biotinylated Detection Ab (100x)
Concentrated HRP Conjugate (100x)
Concentrated Wash Buffer (25x)
HRP Conjugate Diluent
Micro ELISA Plate (Dismountable)
Plate Sealer
Product Manual
Reference Standard
Sample Diluent
Stop Solution
Substrate Reagent

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: IL-18 BPa

IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).

Long Name

Interleukin 18 Binding Protein Isoform a

Alternate Names

IL18 BPa, IL18BP

Gene Symbol

IL18BP

Additional IL-18 BPa Products

Product Documents for Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

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Download Manual - Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

Certificate of Analysis

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Product Specific Notices for Rat IL-18 BPa/IL18BP ELISA Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Related Research Areas

IL-1 Family

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