Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50
= 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c
by Bid-induced Bax activation (IC50
= 0.68 μ
Soluble to 5 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
Bombrun et al.
MAC inhibitors suppress mitochondrial apoptosis.
Peixoto et al.