iMAC2

Key Product Details

Product Description

iMAC2 is an inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC₅₀ = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC₅₀ = 0.68 μM).

Product Specifications for iMAC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for iMAC2

The following data is based on the product molecular weight 542.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	36.89 mL	184.46 mL	368.93 mL
0.25 mM	7.38 mL	36.89 mL	73.79 mL
0.5 mM	3.69 mL	18.45 mL	36.89 mL
2.5 mM	0.74 mL	3.69 mL	7.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Peixoto MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 2009 PMID: 19691447
• Bombrun 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 2003 PMID: 14521400

Product Documents for iMAC2