IRF9 Antibody (PCRP-IRF9-2F8) [Biotin]

Novus Biologicals | Catalog # NBP3-14228B

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Protein Array

Label

Biotin

Antibody Source

Monoclonal Mouse IgG2A Clone # PCRP-IRF9-2F8
View all IRF9 Primary Antibodies »

Product Specifications

Immunogen

Recombinant full-length human IRF9 protein (Uniprot: Q00978)

Reactivity Notes

0

Localization

Cytoplasm, Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for IRF9 Antibody (PCRP-IRF9-2F8) [Biotin]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Protein Array

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: IRF9

Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state

Long Name

Interferon Regulatory Factor 9

Alternate Names

ISGF3, ISGF3G

Gene Symbol

IRF9

Additional IRF9 Products

Product Documents for IRF9 Antibody (PCRP-IRF9-2F8) [Biotin]

Certificate of Analysis

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Product Specific Notices for IRF9 Antibody (PCRP-IRF9-2F8) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

No product specific FAQs exist for this product.

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Associated Pathways

Jak/STAT Signaling Pathway Jak/STAT Signaling Pathway Thumbnail