Irsogladine maleate
Chemical Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
Purity: ≥99%
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine.
Nozaki et al.
Breast Cancer Res.Treat., 2004;83:195 -
Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats.
Kyoi et al.
J.Pharmacol.Sci., 2004;95:321 -
Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils.
Kyoi et al.
Life Sci., 2004;76:71
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