Chemical Name: 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Biological ActivityPre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
O'Brien et al.
The right tool for the job.
Szewczak et al.
Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis.
Boswell et al.
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