Isoginkgetin

Catalog # Availability Size / Price Qty
6483/10
Cat.No. 6483 - Isoginkgetin | C32H22O10 | CAS No. 548-19-6
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Description: Pre-mRNA splicing inhibitor; cell permeable

Chemical Name: 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Reviews

Biological Activity

Pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable

Technical Data

M.Wt:
566.51
Formula:
C32H22O10
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
548-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
    O'Brien et al.
    J.Biol.Chem., 2008;283:33147
  2. The right tool for the job.
    Szewczak et al.
    Cell, 2017;169:561
  3. Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis.
    Boswell et al.
    Nat.Chem.Biol., 2017;13:501

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