Catalog Number: 4088
Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Biological Activity
Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.
Technical Data
  • M.Wt:
    300.37
  • Formula:
    C18H21FN2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    314245-33-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Enhancement of proteasome activity by a small-molecule inhibitor of USP14.
    Lee et al.
    Nature, 2010;467:179
  2. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.
    Lee et al.
    Mol.Cell.Proteomics, 2010;10:R110

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