JW 642

Key Product Details

Product Description

JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC₅₀ = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC₅₀ = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).

Licensing Information

Sold under license from The Scripps Research Institute

Product Specifications for JW 642

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JW 642

The following data is based on the product molecular weight 462.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.81 mL	21.63 mL
5 mM	0.43 mL	2.16 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chang Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 2012 PMID: 22542104

Product Documents for JW 642