KC 12291 hydrochloride

Discontinued Product

3251 has been discontinued.
View all Voltage-gated Sodium Channel Blockers products.
KC 12291 hydrochloride | CAS No. 181936-98-1 | Voltage-gated Sodium Channel Blockers
1 Image
Description: Orally active atypical Na+ channel blocker; cardioprotective

Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride

Purity: ≥97%

Product Details

Biological Activity

KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Technical Data

Soluble to 25 mM in water and to 50 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.
    Tamareille et al.
    J.Cardiovasc.Pharmacol., 2002;40:346
  2. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.
    John et al.
    Cardiovasc.Drug Rev., 2004;22:17
  3. Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
    Letienne et al.
    Eur.J.Pharmacol., 2006;530:243
  4. Cardioprotective actions of KC 12291.
    Decking et al.
    Naunyn-Schmied.Arch.Pharmacol., 1998;358:547

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for KC 12291 hydrochloride

There are currently no reviews for this product. Be the first to review KC 12291 hydrochloride and earn rewards!

Have you used KC 12291 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.