KC 12291 hydrochloride
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
Biological ActivityOrally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.
Tamareille et al.
KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.
John et al.
Cardiovasc.Drug Rev., 2004;22:17
Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
Letienne et al.
Cardioprotective actions of KC 12291.
Decking et al.
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