Catalog Number: 3251
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
Biological Activity
Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.
    Tamareille et al.
    J.Cardiovasc.Pharmacol., 2002;40:346
  2. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.
    John et al.
    Cardiovasc.Drug Rev., 2004;22:17
  3. Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
    Letienne et al.
    Eur.J.Pharmacol., 2006;530:243
  4. Cardioprotective actions of KC 12291.
    Decking et al.
    Naunyn-Schmied.Arch.Pharmacol., 1998;358:547

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