Catalog Number: 5215
Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
Biological Activity
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).
Technical Data
  • M.Wt:
    599.03
  • Formula:
    C26H29ClN2O4S.H3PO4
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1188890-41-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
    Anderson et al.
    J.Pharmacol.Exp.Ther., 1998;287:996
  2. KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated
    Rezazadeh et al.
    J.Pharmacol.Exp.Ther., 2006;317:292
  3. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine content in PC12h cells.
    Sumi et al.
    Biochem.Biophys.Res.Comm., 1991;181:968
  4. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II.
    Bruno et al.
    Synthesis, 2010;24:4193
Tocris Small Molecules
Description Application Cat# Citations Images  

KN 93

1278 17  
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