KN 93 phosphate

Tocris Bioscience | Catalog # 5215

CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
Tocris Bioscience

Key Product Details

Description

CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
View all CaM Kinase Inhibitors »

Product Description

KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

Product Specifications for KN 93 phosphate

Molecular Weight

599.03

Formula

C26H29ClN2O4S.H3PO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate

CAS Number

1188890-41-6

PubChem ID

16760530

InChI Key

NNKJTPOXLIILMB-IPZCTEOASA-N

SMILES

O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O.O=P(O)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.99 10

Preparing Stock Solutions for KN 93 phosphate

The following data is based on the product molecular weight 599.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.69 mL 83.47 mL 166.94 mL
0.5 mM 3.34 mL 16.69 mL 33.39 mL
1 mM 1.67 mL 8.35 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for KN 93 phosphate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KN 93 phosphate

For research use only

Citations for KN 93 phosphate

Customer Reviews for KN 93 phosphate (1)

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  • KN93 phosphate inhibits HOCl-LDL-reduced Ca2+ transient amplitude in cardiomyocytes
    Name: Christopher Trummer
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/22/2018
    Guinea pig ventricular cardiomyocytes were incubated with KN93 phosphate (5 µM, 30 min) prior to HOCl-LDL (250 µg/ml, 14 h) addition followed by loading of cells with Fura-2AM. Cells were stimulated at a 1 Hz frequency and Ca2+ transient (CaT) amplitude was analyzed. KN93 phosphate significantly inhibited HOCl-LDL-reduced CaT amplitude
    KN 93 phosphate 5215

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