Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide
Biological ActivityKN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.
Water soluble form and Negative Control also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells.
Sumi et al.
KN-93 inhibits IKr in mammalian cardiomyocytes.
Hegyi et al.
Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells.
Patel et al.
KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated
Rezazadeh et al.
Citations for KN 93
The citations listed below are publications that use Tocris products. Selected citations for KN 93 include:
23 Citations: Showing 1 - 10
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
Authors: Weng Et al.
WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
Authors: Abedini Et al.
FASEB J 2016;30:1534
Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of β-amyloid.
Authors: Raka Et al.
Mol Brain 2015;8:21
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
Authors: Draganov Et al.
Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
Authors: Cohen Et al.
PLoS One 2015;460:88
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
Authors: Bonnefond Et al.
Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
Authors: Nygaard Et al.
Biochem Biophys Res Commun 2015;1:82
Activation of Phosphatidylinositol-Linked DA Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex.
Authors: Glovaci and Chapman
PLoS One 2015;10:e0131948
SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
Authors: Wang Et al.
PLoS One 2014;8:e83941
Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching.
Authors: Guemez-Gamboa Et al.
Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.
Authors: Hill and Muldrew
Clin Exp Pharmacol Physiol 2014;41:430
Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats.
Authors: Arguello Et al.
Psychopharmacology (Berl) 2014;231:55
CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Authors: Bemben Et al.
Nat Neurosci 2014;17:56
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
Biochem Pharmacol 2013;8:e66404
AMP-activated protein kinase as regulator of P2Y(6) receptor-induced Ins secretion in mouse pancreatic β-cells.
Authors: Balasubramanian Et al.
J Neurosci 2013;85:991
Increased neuronal activity fragments the Golgi complex.
Authors: Thayer Et al.
Proc Natl Acad Sci U S A 2013;110:1482
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
Authors: Gaamouch Et al.
J Neurosci 2012;32:10767
Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
Authors: Mockett Et al.
J Neurosci 2011;31:7380
HyperDArgic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
Authors: Xu Et al.
Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts.
Authors: Pedersen Et al.
Acta Physiol (Oxf) 2009;197:13
Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
Authors: Kim and Tsien
NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
Authors: Marsden Et al.
J Neurosci 2007;27:14326
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