KN 92

Tocris Bioscience | Catalog # 4130

Inactive analog of KN 93. K+ channel (Kv) blocker
Tocris Bioscience

Key Product Details

Description

Inactive analog of KN 93. K+ channel (Kv) blocker
View all Additional Calcium Binding Protein Modulators »

Product Description

KN 92 is an inactive analog of the CaM kinase II inhibitor KN 93 . Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.

Active Analog also available.

Product Specifications for KN 92

Molecular Weight

554.98

Formula

C24H25ClN2O3S.H3PO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate

CAS Number

1135280-28-2

PubChem ID

16219540

InChI Key

XRQHWVVDNMJDEQ-IPZCTEOASA-N

SMILES

ClC1=CC=C(/C=C/CN(C)CC2=CC=CC=C2NS(=O)(C3=CC=C(OC)C=C3)=O)C=C1.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.55 10

Preparing Stock Solutions for KN 92

The following data is based on the product molecular weight 554.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.02 mL 90.09 mL 180.19 mL
0.5 mM 3.60 mL 18.02 mL 36.04 mL
1 mM 1.80 mL 9.01 mL 18.02 mL
5 mM 0.36 mL 1.80 mL 3.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 42 publications citing the usage of this product.

Product Documents for KN 92

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KN 92

For research use only

Customer Reviews for KN 92 (1)

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  • KN93 but not KN92 reduces maximum upstroke velocity of cardiac action potential
    Name: Christopher Trummer
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/22/2018
    Guinea pig ventricular cardiomyocytes were treated (12-16 h) with KN93 (5 µM), KN92 (5 µM) or Ranolazine (10 µM). Cells were patched and stimulated at a 1 Hz frequency to record action potential. Maximum upstroke velocity was significantly was reduced by KN93 while KN92 was ineffective.
    KN 92 4130

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