Kobe 0065

Key Product Details

Product Description

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.

Product Specifications for Kobe 0065

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Kobe 0065

The following data is based on the product molecular weight 449.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.23 mL	111.16 mL	222.33 mL
0.5 mM	4.45 mL	22.23 mL	44.47 mL
1 mM	2.22 mL	11.12 mL	22.23 mL
5 mM	0.44 mL	2.22 mL	4.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Shima In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23630290

Product Documents for Kobe 0065