Catalog Number: 5475
Chemical Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
Biological Activity
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.
Technical Data
  • M.Wt:
    449.79
  • Formula:
    C15H11ClF3N5O4S
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 5 mM in water with gentle warming
  • Storage:
    Store at +4°C
  • CAS No:
    436133-68-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
    Shima et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:8182

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