Catalog Number: 1131
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-1H-imidazole
Biological Activity
Antagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent insulin secretagogue in rat and human islets of Langerhans.
    Chan et al.
    Br.J.Pharmacol., 1997;120:926
  2. Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets.
    Chan et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:763
  3. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse.
    Mayer and Taberner
    Eur.J.Pharmacol., 2002;454:95
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