Catalog Number: 1979
Chemical Name: N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate
Biological Activity
Potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.
Technical Data
  • M.Wt:
    599.56
  • Formula:
    C25H29F2N5O3.CF3CO2H
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    217480-26-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
    Rohrer et al.
    Science, 1998;282:737
  2. Identification and characterization of subtype selective somatostatin receptor agonists.
    Rohrer and Schaeffer
    J.Physiol.Paris, 2000;94:211
  3. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice.
    Moneta et al.
    Eur.J.Neurosci., 2002;16:843

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