Potent and selective somatostatin sst4
receptor agonist. Ki
values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4
receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro
and increases kainate-induced seizures in mice in vivo
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Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer et al.
Identification and characterization of subtype selective somatostatin receptor agonists.
Rohrer and Schaeffer
Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice.
Moneta et al.