L-Dehydroascorbic acid
Discontinued Product
5734 has been discontinued.
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Description: GLUT1 substrate; oxidized form of L-Ascorbic acid
Chemical Name: L-threo-2,3-Hexodiulosonic acid γ-lactone
Biological Activity
L-Dehydroascorbic acid is a oxidized form of L-Ascorbic acid (Cat. No. 4055). Transported into cells through GLUT1. Selectively induces cell death in KRAS and BRAF mutant cells in vitro.Technical Data
M.Wt:
174.11
Formula:
C6H6O6
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
490-83-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Vitamin C could target some common cancers.
Kaiser
Science, 2015;6:6261 -
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Yun et al.
Science, 2015;11:6266
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