L-Glutathione Reduced

Tocris Bioscience | Catalog # 5219

Endogenous antioxidant
Tocris Bioscience
Discontinued Product
5219 has been discontinued. View all Additional Antioxidant Compounds products.

Key Product Details

Description

Endogenous antioxidant

Alternative Names

GSH
View all Additional Antioxidant Compounds »

Product Description

L-Glutathione Reduced is an endogenous antioxidant; reduces reactive oxygen species formed during cellular metabolism. Regulates activity of the redox sensitive transcription factor NF-κB. Cytoprotective.

Product Specifications for L-Glutathione Reduced

Molecular Weight

307.32

Formula

C10H17N3O6S

Storage

Store at +4°C

Purity

≥98%

Chemical Name

L-γ-glutamyl-L-cysteinyl-glycine

CAS Number

70-18-8

PubChem ID

124886

InChI Key

RWSXRVCMGQZWBV-WDSKDSINSA-N

SMILES

O=C(N[C@@H](CS)C(NCC(O)=O)=O)CC[C@H](N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.73 100

Preparing Stock Solutions for L-Glutathione Reduced

The following data is based on the product molecular weight 307.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for L-Glutathione Reduced

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-Glutathione Reduced

For research use only

Citations for L-Glutathione Reduced

Customer Reviews for L-Glutathione Reduced (3)

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  • Great product
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 07/02/2019
    used it for generating a reducing environment in-vitro
    used at 14mM aq. solution for kinetics experiments.
  • GSH did not inhibit the LPA induced expression of pAMPK in microglia.
    Name: lisha joshi
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BV2 microglia cells
    Verified Customer | Posted 06/18/2019
    GSH was used at a concentration 10µM and was well tolerated by the cells. BV2 cells were pre incubated with the inhibitor for one and then treated with 1µM LPA. Western blot analysis revealed that GSH incubation did not abolish the LPA induced expression of pAMPK in BV2 microglia cells.
    L-Glutathione Reduced 5219
  • GSH inhibits 15d-PGJ2-induced apoptosis in osteosarcoma cells
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MG-63 osteosarcoma cells
    Verified Customer | Posted 10/15/2018
    MG-63 cells were incubated with GSH (10 μM) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 24 h to follow apoptotic markers using Western blot. GSH inhibited 15d-PGJ2-induced PARP and Caspase-3 cleavage.
    L-Glutathione Reduced 5219

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