Antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro
. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. Also triggers apoptosis in colon cancer cells. Cell permeable.
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LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.
Yang et al.
Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.
Steinstraesser et al.
Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer.
Ren et al.
Cancer Res., 2012;72:6512
Spotlight on human LL-37, an immunomodulatory peptide with promising cell-penetrating properties.
Seil et al.