Catalog Number: 5213
Biological Activity
Antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. Also triggers apoptosis in colon cancer cells. Cell permeable.
Technical Data
  • M.Wt:
    4493.32
  • Formula:
    C205H340N60O53
  • Sequence:
    LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    154947-66-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.
    Yang et al.
    J.Exp.Med., 2000;192:1069
  2. Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.
    Steinstraesser et al.
    Mol.Ther., 2014;22:734
  3. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer.
    Ren et al.
    Cancer Res., 2012;72:6512
  4. Spotlight on human LL-37, an immunomodulatory peptide with promising cell-penetrating properties.
    Seil et al.
    Pharmaceuticals, 2010;3:3435

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