Chemical Name: N-Acetyl-2-benzyltryptamine
Biological ActivityLuzindole is a melatonin antagonist.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Melatonin receptors: are there multiple subtypes?
Luzindole (N-0774): a novel melatonin receptor antagonist.
Anti-depressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in mouse behavioural despair test.
Dubocovich et al.
Citations for Luzindole
The citations listed below are publications that use Tocris products. Selected citations for Luzindole include:
16 Citations: Showing 1 - 10
Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin
Authors: Letra-Vilela Et al.
Molecular and Cellular Endocrinology 2016;434:238
Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway.
Authors: Cecon Et al.
FASEB J 2015;29:2566
The melatonin agonist rame. induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.
Authors: Nishiyama and Hirai
PLoS One 2014;9:e102073
Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
Authors: Chen Et al.
J Clin Invest 2014;20:1298
Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state.
Authors: Legros Et al.
Br J Pharmacol 2014;171:186
NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.
Authors: Muxel Et al.
Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
Authors: Baba Et al.
Sci Signal 2013;6:ra89
Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.
Authors: Faria Et al.
Am J Physiol Endocrinol Metab 2013;305:E230
MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
Authors: Tunstall Et al.
J Neuroinflammation 2011;336:127
Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
Authors: Kojima Et al.
Br J Pharmacol 2011;162:1179
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Authors: Mickle Et al.
Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro.
Authors: Silva Et al.
Br J Pharmacol 2007;151:195
Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
Authors: Savinainen Et al.
Br J Pharmacol 2005;145:636
Cyclical regulation of GnRH gene expression in GT1-7 GnRH-Secr.g neurons by melatonin.
Authors: Roy Et al.
World J Gastroenterol 2001;142:4711
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Authors: Sjöblom Et al.
J Pharmacol Exp Ther 2001;108:625
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