Catalog # Availability Size / Price Qty
Luzindole | CAS No. 117946-91-5 | Melatonin (MT) Receptor Antagonists
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Description: Competitive melatonin MT1/MT2 antagonist

Chemical Name: N-Acetyl-2-benzyltryptamine

Purity: ≥99%

Product Details
Citations (16)
Supplemental Products

Biological Activity

Luzindole is a melatonin antagonist.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Luzindole

The citations listed below are publications that use Tocris products. Selected citations for Luzindole include:

16 Citations: Showing 1 - 10

  1. Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
    Authors: Hou Et al.
    Front Cell Neurosci  2017;11:98
  2. Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin
    Authors: Letra-Vilela Et al.
    Molecular and Cellular Endocrinology  2016;434:238
  3. Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway.
    Authors: Cecon Et al.
    FASEB J  2015;29:2566
  4. The melatonin agonist rame. induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.
    Authors: Nishiyama and Hirai
    PLoS One  2014;9:e102073
  5. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
    Authors: Chen Et al.
    J Clin Invest  2014;20:1298
  6. Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state.
    Authors: Legros Et al.
    Br J Pharmacol  2014;171:186
  7. NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.
    Authors: Muxel Et al.
    Endocrinology  2013;7:e52010
  8. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
    Authors: Baba Et al.
    Sci Signal  2013;6:ra89
  9. Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.
    Authors: Faria Et al.
    Am J Physiol Endocrinol Metab  2013;305:E230
  10. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
    Authors: Tunstall Et al.
    J Neuroinflammation  2011;336:127


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