Catalog Number: 0877
Chemical Name: N-Acetyl-2-benzyltryptamine
Biological Activity
Melatonin antagonist.
Technical Data
  • M.Wt:
    292.38
  • Formula:
    C19H20N2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    117946-91-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melatonin receptors: are there multiple subtypes?
    Dubocovich
    TiPS, 1995;16:50
  2. Anti-depressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in mouse behavioural despair test.
    Dubocovich et al.
    Eur.J.Pharmacol., 1990;182:313
  3. Luzindole (N-0774): a novel melatonin receptor antagonist.
    Dubocovich
    J.Pharmacol.Exp.Ther., 1988;246:902
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Luzindole include:

10 Citations: Showing 1 - 10
Filter your results:

  1. Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin
    Authors: Letra-Vilela Et al.
    Molecular and Cellular Endocrinology 2016;434:238
  2. The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.
    Authors: Nishiyama and Hirai
    PLoS One 2014;9:e102073
  3. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
    Authors: Chen Et al.
    J Clin Invest 2014;20:1298
  4. Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state.
    Authors: Legros Et al.
    Br J Pharmacol 2014;171:186
  5. NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.
    Authors: Muxel Et al.
    Endocrinology 2013;7:e52010
  6. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
    Authors: Tunstall Et al.
    J Neuroinflammation 2011;336:127
  7. Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
    Authors: Kojima Et al.
    Br J Pharmacol 2011;162:1179
  8. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
    Authors: Savinainen Et al.
    Br J Pharmacol 2005;145:636
  9. Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.
    Authors: Roy Et al.
    World J Gastroenterol 2001;142:4711
  10. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
    Authors: Sjöblom Et al.
    J Pharmacol Exp Ther 2001;108:625

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