LY 2955303

Key Product Details

Product Description

LY 2955303 is a high affinity and selective RARγ antagonist (K_i values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.

Product Specifications for LY 2955303

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 2955303

The following data is based on the product molecular weight 578.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.64 mL	43.20 mL	86.39 mL
1 mM	1.73 mL	8.64 mL	17.28 mL
2 mM	0.86 mL	4.32 mL	8.64 mL
10 mM	0.17 mL	0.86 mL	1.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hughes Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Letts. 2016 PMID: 27261179

Product Documents for LY 2955303