LY 364947

Catalog # Availability Size / Price Qty
2718/1
2718/10
LY 364947 | CAS No. 396129-53-6 | TGF-beta Receptor Inhibitors
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Description: Selective inhibitor of TGF-βRI
Alternative Names: HTS 466284

Chemical Name: 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

Technical Data

M.Wt:
272.31
Formula:
C17H12N4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
396129-53-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for LY 364947

The citations listed below are publications that use Tocris products. Selected citations for LY 364947 include:

11 Citations: Showing 1 - 10

  1. Cell Type-Specific TGF-β Mediated EMT in 3D and 2D Models and Its Reversal by TGF-β Receptor Kinase Inhibitor in Ovarian Cancer Cell Lines.
    Authors: Ameri Et al.
    Int J Mol Sci  2019;20
  2. NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.
    Authors: Wang Et al.
    Brain Struct Funct  2017;222:1543
  3. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow.
    Authors: Yumoto Et al.
    Sci Rep  2016;6:36520
  4. TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.
    Authors: Oshimori Et al.
    Cell  2015;160:963
  5. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
    Authors: Oruqaj Et al.
    Proc Natl Acad Sci U S A  2015;112:E2048
  6. RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression.
    Authors: Jajosky Et al.
    Stem Cells Transl Med  2014;3:836
  7. Cyclic AMP enhances TGFβ responses of breast cancer cells by upregulating TGFβ receptor I expression.
    Authors: Oerlecke Et al.
    PLoS One  2013;8:e54261
  8. Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells.
    Authors: Sethi Et al.
    Invest Ophthalmol Vis Sci  2013;113:117
  9. Tgf-β induced Erk phosphorylation of smad linker region regulates smad signaling.
    Authors: Hough Et al.
    Invest Ophthalmol Vis Sci  2012;7:e42513
  10. Role of TGFβ/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins.
    Authors: Sethi Et al.
    PLoS One  2011;52:5251

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