LY 367385

  ( 39 citations )    
Product Datasheet
Catalog Number:1237
Chemical Name:(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
Product Details
Citations (39)
Supplemental Products
Reviews
Biological Activity
A selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    209.2
  • Formula:
    C10H11NO4
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    198419-91-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 367385 include:

39 Citations: Showing 1 - 10
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  1. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
    Authors: Dornier
    Nat Commun  2017;8(1):2255
  2. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Proc Natl Acad Sci U S A  2015;35:5664
  3. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
    Authors: Tang and Alger
    J Neurosci  2015;35:3938
  4. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurophysiol  2015;35:308
  5. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
    Authors: Galván Et al.
    Neuroscience  2015;290:332
  6. Metaplastic Regulation of CA1 Schaffer Collateral Pathway Plasticity by Hebbian MGluR1a-Mediated Plasticity at Excitatory Synapses onto Somatostatin-Expressing Interneurons(1,2,3).
    Authors: Vasuta Et al.
    J Neurosci  2015;2
  7. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
    Authors: Hullinger Et al.
    Neurobiol Learn Mem  2015;125:126
  8. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  9. Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
    Authors: Armbrust Et al.
    J Neurosci  2014;34:9891
  10. Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons.
    Authors: Dominguez Et al.
    J Neurosci  2013;78:607
  11. The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling.
    Authors: Boulware Et al.
    Mol Pharmacol  2013;33:15184
  12. Norepinephrine enhances a discrete form of long-term depression during fear memory storage.
    Authors: Clem and Huganir
    J Neurosci  2013;33:11825
  13. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One  2012;7:e45717
  14. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
    Authors: Bozdagi Et al.
    Steroids  2012;7:e42422
  15. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
    Authors: Peterfi Et al.
    J Neurosci  2012;32:14448
  16. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  17. Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
    Authors: Zhang and Lisman
    Eneuro  2012;107:1058
  18. Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
    Authors: Krishnan Et al.
    PLoS One  2011;6:e25639
  19. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
    Authors: Hays Et al.
    J Neurosci  2011;31:14223
  20. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.
    Authors: Reissner Et al.
    J Neurosci  2010;30:8797
  21. Modulator property of the intrinsic cortical projection from layer 6 to layer 4.
    Authors: Lee and Sherman
    Front Syst Neurosci  2009;3:3
  22. Subthreshold glutamate release from mitral cell dendrites.
    Authors: Castro and Urban
    J Neurosci  2009;29:7023
  23. Estradiol-induced estrogen receptor-α trafficking.
    Authors: Bondar Et al.
    J Neurosci  2009;29:15323
  24. Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses.
    Authors: Holbro Et al.
    Proc Natl Acad Sci U S A  2009;106:15055
  25. The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.
    Authors: Zhang Et al.
    J Neurosci  2008;28:10561
  26. Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
    Authors: Neyman and Manahan-Vaughan
    Eur J Neurosci  2008;27:1345
  27. Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
    Authors: Fanselow Et al.
    J Neurophysiol  2008;100:2640
  28. AMPAR exocytosis through NO modulation of PICK1.
    Authors: Sossa Et al.
    J Neurosci  2007;53:92
  29. Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.
    Authors: Xu Et al.
    Neuron  2007;53:399
  30. Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
    Authors: Kirschstein Et al.
    J Neurosci  2007;27:7696
  31. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
    Authors: Muddashetty Et al.
    J Neurosci  2007;27:5338
  32. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
    Authors: Nakamoto Et al.
    Proc Natl Acad Sci U S A  2007;104:15537
  33. Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction.
    Authors: Keuren-Jensen and Cline
    J Neurosci  2006;26:7575
  34. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.
    Authors: Jung Et al.
    Br J Pharmacol  2005;68:1196
  35. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci  2005;25:2245
  36. Endocannabinoid-mediated metaplasticity in the hippocampus.
    Authors: Chevaleyre and Castillo
    Neuron  2004;43:871
  37. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
    Authors: Gallagher Et al.
    J Neurosci  2004;24:4859
  38. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci  2004;24:4551
  39. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    PLoS One  2003;100:1322
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