Chemical Name: (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
Biological ActivityA selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept
Bruno et al.
Anticonvulsant actions of LY 367385 ((+)-methyl-4-carboxyphenylglycine), and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).
Chapman et al.
Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine.
Salt and Turner
(+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors.
Clark et al.
Citations for LY 367385
The citations listed below are publications that use Tocris products. Selected citations for LY 367385 include:
47 Citations: Showing 1 - 10
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Authors: Nam Et al.
Cell Rep 2019;28:1154
A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
Authors: Hellmer Et al.
Physiol Rep 2018;6:e13885
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.
Authors: Thalman Et al.
Mol Psychiatry 2018;23(8):1699
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
Authors: Adamsky Et al.
Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings.
Authors: Vergassola Et al.
Front Mol Neurosci 2018;11:324
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Authors: Hashimotodani Et al.
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
Nat Commun 2017;8(1):2255
Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
Proc Natl Acad Sci U S A 2015;35:5664
Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
Authors: Tang and Alger
J Neurosci 2015;35:3938
Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Authors: Zhao Et al.
J Neurophysiol 2015;35:308
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Metaplastic Regulation of CA1 Schaffer Collateral Pathway Plasticity by Hebbian MGluR1a-Mediated Plasticity at Excitatory Synapses onto Somatostatin-Expressing Interneurons(1,2,3).
Authors: Vasuta Et al.
J Neurosci 2015;2
Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
Authors: Hullinger Et al.
Neurobiol Learn Mem 2015;125:126
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Authors: Kubota Et al.
PLoS One 2014;9:e106316
Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
Authors: Armbrust Et al.
J Neurosci 2014;34:9891
Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
PLoS One 2013;8:e71155
Membrane-initiated OE signaling in immortalized hypothalamic N-38 neurons.
Authors: Dominguez Et al.
J Neurosci 2013;78:607
The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling.
Authors: Boulware Et al.
Mol Pharmacol 2013;33:15184
NE enhances a discrete form of long-term depression during fear memory storage.
Authors: Clem and Huganir
J Neurosci 2013;33:11825
Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
Authors: Jurgens Et al.
PLoS One 2012;7:e45717
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
Authors: Bozdagi Et al.
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
Authors: Peterfi Et al.
J Neurosci 2012;32:14448
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
Authors: Zhang and Lisman
DA-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
Authors: Krishnan Et al.
PLoS One 2011;6:e25639
Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
Authors: Hays Et al.
J Neurosci 2011;31:14223
A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.
Authors: Reissner Et al.
J Neurosci 2010;30:8797
Modulator property of the intrinsic cortical projection from layer 6 to layer 4.
Authors: Lee and Sherman
Front Syst Neurosci 2009;3:3
Subthreshold glutamate release from mitral cell dendrites.
Authors: Castro and Urban
J Neurosci 2009;29:7023
OE-induced estrogen receptor-α trafficking.
Authors: Bondar Et al.
J Neurosci 2009;29:15323
Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses.
Authors: Holbro Et al.
Proc Natl Acad Sci U S A 2009;106:15055
The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.
Authors: Zhang Et al.
J Neurosci 2008;28:10561
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Authors: Neyman and Manahan-Vaughan
Eur J Neurosci 2008;27:1345
Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
Authors: Fanselow Et al.
J Neurophysiol 2008;100:2640
AMPAR exocytosis through NO modulation of PICK1.
Authors: Sossa Et al.
J Neurosci 2007;53:92
Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.
Authors: Xu Et al.
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Authors: Kirschstein Et al.
J Neurosci 2007;27:7696
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
Authors: Muddashetty Et al.
J Neurosci 2007;27:5338
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Authors: Nakamoto Et al.
Proc Natl Acad Sci U S A 2007;104:15537
Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction.
Authors: Keuren-Jensen and Cline
J Neurosci 2006;26:7575
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.
Authors: Jung Et al.
Br J Pharmacol 2005;68:1196
Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
Authors: Calò Et al.
J Neurosci 2005;25:2245
Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons.
Authors: Wu Et al.
J Neurophysiol 2004;92:1216
Endocannabinoid-mediated metaplasticity in the hippocampus.
Authors: Chevaleyre and Castillo
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
Authors: Gallagher Et al.
J Neurosci 2004;24:4859
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Authors: Huang Et al.
J Neurosci 2004;24:4551
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Authors: Nishi Et al.
PLoS One 2003;100:1322
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Retinal dissections were performed in HEPES-buffered extracellular solution containing inhibitor cocktail containing 100 umol/L LY 367385