LY 367385

Tocris Bioscience | Catalog # 1237

Selective mGlu1a antagonist
Tocris Bioscience

Key Product Details

Description

Selective mGlu1a antagonist
View all Group I mGluR Antagonists »

Product Description

LY 367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors.

Licensing Information

Sold with the permission of Eli Lilly and Company

Product Specifications for LY 367385

Molecular Weight

209.20

Formula

C10H11NO4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid

CAS Number

198419-91-9

PubChem ID

5311261

InChI Key

SGIKDIUCJAUSRD-QMMMGPOBSA-N

SMILES

N[C@H](C(O)=O)C1=C(C)C=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 10.46 50 with gentle warming with sonication

Preparing Stock Solutions for LY 367385

The following data is based on the product molecular weight 209.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.56 mL 47.80 mL 95.60 mL
2.5 mM 1.91 mL 9.56 mL 19.12 mL
5 mM 0.96 mL 4.78 mL 9.56 mL
25 mM 0.19 mL 0.96 mL 1.91 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 270 publications citing the usage of this product.

Product Documents for LY 367385

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 367385

For research use only

Customer Reviews for LY 367385 (1)

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  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Verified Customer | Posted 12/03/2019
    Retinal dissections were performed in HEPES-buffered extracellular solution containing inhibitor cocktail containing 100 umol/L LY 367385
    LY 367385 1237

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