Human mGluR1 (AAB05337) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC0983
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Human mGluR1 (AAB05337) VersaClone cDNA Summary

Metabotropic glutamate receptor 1 (mGluR1) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19-592). The ECD binds glutamate and forms either a covalent homodimer or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33-522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: mGluR1

Long Name
Metabotropic Glutamate Receptor 1
Entrez Gene IDs
2911 (Human); 14816 (Mouse); 24414 (Rat)
Alternate Names
glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; metabotropic glutamate receptor 1; mGluR1; MGLUR1A; MGLUR1GPRC1AmGlu1

Reagents Provided

FAQs

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Tocris Small Molecules

Ro 67-4853

YM 230888

Ro 01-6128

CPPHA

Theanine

AZD 9272

FTIDC

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