MCOPPB trihydrochloride

Key Product Details

Product Description

MCOPPB trihydrochloride is a high affinity NOP receptor agonist (pK_i = 10.07 for the human NOP receptor). Exhibits anxiolytic effects with no effect on memory or locomotion. Regarded as one of the most potent, non-peptide NOP full agonists in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for MCOPPB trihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MCOPPB trihydrochloride

The following data is based on the product molecular weight 534.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.6 mM	3.12 mL	15.60 mL	31.21 mL
3 mM	0.62 mL	3.12 mL	6.24 mL
6 mM	0.31 mL	1.56 mL	3.12 mL
30 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hayashi Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain f J.Med.Chem. 2009 PMID: 19125610
• Hirao Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J.Pharmacol.Sci. 2008 PMID: 18319566

Product Documents for MCOPPB trihydrochloride