Melanocyte-stimulating hormone release inhibiting factor

Name: Melanocyte-stimulating hormone release inhibiting factor
Brand: Tocris Bioscience
SKU: 1929
Price: 80 USD

Catalog #: 1929 Datasheet / COA / SDS

Discontinued Product

1929 has been discontinued.

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Melanocyte-stimulating hormone release inhibiting factor

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Description: Inhibitor of α-MSH release; inhibits opioid effects in vivo

Alternative Names: Pro-Leu-Gly amide,MIF-I,PLG

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Biological Activity

Melanocyte-stimulating hormone release inhibiting factor is a inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.

Technical Data

M.Wt:

284.36

Formula:

C₁₃H₂₄N₄O₃

Sequence:

PLG

(Modifications: Gly-3 = C-terminal amide)

Storage:

Desiccate at -20°C

CAS No:

2002-44-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity.
Kavaliers and Hirst
Brain Res., 1986;372:370
Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-MthD.-leucyl-glycinamide and MIF on biogenic amine turnover.
Pugsley and Lippmann
Arzneimittelforschung, 1977;27:2293
Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review.
Mishra et al.
Methods Find.Exp.Clin.Pharmacol., 1983;5:203
Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide.
Plotnikoff and Kastin
Arch.Int.Pharmacodyn.Ther., 1974;211:211

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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