Melanocyte-stimulating hormone release inhibiting factor is a inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.

Product Specifications for Melanocyte-stimulating hormone release inhibiting factor

Molecular Weight

284.36

Formula

C₁₃H₂₄N₄O₃

Storage

Desiccate at -20°C

CAS Number

2002-44-0

PubChem ID

92910

InChI Key

NOOJLZTTWSNHOX-UWVGGRQHSA-N

SMILES

[H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Pugsley and Lippmann Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-MthD.-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 1977 PMID: 23796
Mishra Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 1983 PMID: 6136640
Plotnikoff and Kastin Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 1974 PMID: 4156639
Kavaliers and Hirst Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 1986 PMID: 2871903

Product Documents for Melanocyte-stimulating hormone release inhibiting factor

Certificate of Analysis

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Product Specific Notices for Melanocyte-stimulating hormone release inhibiting factor

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Nutrition and Appetite

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Melanocyte-stimulating hormone release inhibiting factor

Tocris Bioscience | Catalog # 1929

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