Catalog Number: 1929
Alternate Names: Pro-Leu-Gly amide, MIF-I, PLG
Biological Activity
Inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Gly-3 = C-terminal amide)

  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity.
    Kavaliers and Hirst
    Brain Res., 1986;372:370
  2. Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review.
    Mishra et al.
    Methods Find.Exp.Clin.Pharmacol., 1983;5:203
  3. Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover.
    Pugsley and Lippmann
    Arzneimittelforschung, 1977;27:2293
  4. Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide.
    Plotnikoff and Kastin
    Arch.Int.Pharmacodyn.Ther., 1974;211:211

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