Metergoline

Tocris Bioscience | Catalog # 0590

5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7
Tocris Bioscience
Discontinued Product
0590 has been discontinued. View all Non-selective 5-HT2 Receptor Antagonists products.

Key Product Details

Description

5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7
View all Non-selective 5-HT2 Receptor Antagonists »

Product Description

Metergoline is an antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.

Product Specifications for Metergoline

Molecular Weight

403.52

Formula

C25H29N3O2

Storage

Store at RT

Chemical Name

[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester

CAS Number

17692-51-2

PubChem ID

28693

InChI Key

WZHJKEUHNJHDLS-QTGUNEKASA-N

SMILES

[H][C@](CNC(OCC5=CC=CC=C5)=O)1C[C@@](C2=CC=CC3=C2C(C4)=CN3C)([H])[C@]4([H])N(C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.35 100

Preparing Stock Solutions for Metergoline

The following data is based on the product molecular weight 403.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.39 mL 24.78 mL
5 mM 0.50 mL 2.48 mL 4.96 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Product Documents for Metergoline

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Metergoline

For research use only

Customer Reviews for Metergoline (1)

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  • Could not dissolve for in vivo use
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 06/17/2019
    Tocris reply: We're sorry to hear that you have experienced problems with the solubility of Metergoline. We would like to make you aware of the following publication where metergoline 10 mg was solubilized in 1 ml of 45% w/v 2‐hydroxypropyl‐ beta ‐cyclodextrin in H2O and the solution lyophilized to form a fully soluble powder (Negri et al., 1998. PMID: 9641552). The powder (460 mg) was then dissolved in 30 ml of saline and injected in a volume of 1–6 ml kg−1 (s.c). We would like to offer a replacement vial if you no longer have any remaining material for attempting this solubilization method. If this is of interest, please contact us at techsupport@bio-techne.com.
    dissolved fine in DMSO, but came out of solution as soon as I added any saline. Would not stay in solution at even 50% DMSO in saline, it precipitated out into a fluffy white solid (picture attached). Also tried to dissolve in 1% ascorbic acid, and that didn't work either (1mg/ml). Also could not dissolve in 10% ascorbic acid (1mg/ml). I tried heating, vortexing, and sonicating with both and could not get it into solution. could not use with with my experiments
    Metergoline 0590

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