Catalog Number: 0590
Chemical Name: [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Biological Activity
Antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.
Technical Data
  • M.Wt:
    403.52
  • Formula:
    C25H29N3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    17692-51-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats.
    Aulakh et al.
    J.Pharmacol.Exp.Ther., 1992;263:588
  2. Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists.
    Bagdy et al.
    Eur.J.Pharmacol., 1992;210:285
  3. Agonist activity of sumatriptan and metergoline at the human 5-HT1Dβ receptor in the action of sumatriptan.
    Miller et al.
    Eur.J.Pharmacol., 1992;227:99
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Metergoline include:

2 Citations: Showing 1 - 2
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  1. Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptoractivation and norepinephrine reuptake inhibition.
    Authors: Wang
    Sci Rep 2017;7:43137
  2. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron 2007;54:599

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