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Metergoline

Catalog #: 0590
4 Citations Datasheet / COA / SDS

Discontinued Product

0590 has been discontinued.
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Metergoline | CAS No. 17692-51-2 | Non-selective 5-HT2 Receptor Antagonists
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Description: 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7

Chemical Name: [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Metergoline is an antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.

Technical Data

M.Wt:
403.52
Formula:
C25H29N3O2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
17692-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Metergoline

The citations listed below are publications that use Tocris products. Selected citations for Metergoline include:

4 Citations: Showing 1 - 4

  1. Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptoractivation and NE reuptake inhibition.
    Authors: Wang
    Sci Rep  2017;7:43137
  2. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
    Authors: Chan Et al.
    PLoS Pathog  2016;12:e1005651
  3. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes.
    Authors: Lee Et al.
    Acta Pharmacol Sin  2014;35:862
  4. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599

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