Mevastatin

Catalog # Availability Size / Price Qty
1526/10
1526/50
Mevastatin | CAS No. 73573-88-3 | HMG-CoA Reductase Inhibitors
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Description: HMG-CoA reductase inhibitor
Alternative Names: Compactin

Chemical Name: (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate

Purity: ≥98%

Product Details
Citations (6)
Reviews

Biological Activity

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data

M.Wt:
390.52
Formula:
C23H34O5
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 50 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
73573-88-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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