Mianserin hydrochloride
Discontinued Product
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
Purity: ≥99%
Biological Activity
Mianserin hydrochloride is a non-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
On the mode of action of mianserin.
Leonard
Adv.Biochem.Psychopharmacol., 1982;31:301 -
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Pharmacol.Rev., 1994;46:157 -
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
J.Med.Chem., 2013;56:1211
Product Datasheets
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Citations for Mianserin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Mianserin hydrochloride include:
2 Citations: Showing 1 - 2
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JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
Authors: Wei Et al.
Am J Physiol Lung Cell Mol Physiol 2010;298:L863
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Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Authors: Mbaki
Br J Pharmacol 2008;155:343
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