Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
Biological ActivityNon-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
On the mode of action of mianserin.
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
Citations for Mianserin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Mianserin hydrochloride include:
2 Citations: Showing 1 - 2
JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
Authors: Wei Et al.
Am J Physiol Lung Cell Mol Physiol 2010;298:L863
Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Br J Pharmacol 2008;155:343
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