Chemical Name: 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole nitrate
Biological ActivityAntifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. Enhances the generation of mature oligodendrocytes from progenitor cells in vitro and promotes myelination in vivo. Attenuates disease severity in a mouse model of multiple sclerosis. Brain penetrant.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.
Hubler et al.
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Najim et al.
Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells.
Chang et al.
Life Sci., 2005;76:2091
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