Midazolam hydrochloride

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2832/10
2832/50
Midazolam hydrochloride | CAS No. 59467-96-8 | GABA-A Receptor Benzodiazepines
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Description: Benzodiazepine agonist
Alternative Names: Dormicum, Ro 21-3981/001

Chemical Name: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride

Product Details
Reviews (2)

Biological Activity

Sedative/hypnotic agent that acts at the GABAA receptor benzodiazepine modulatory site.

Technical Data

Formula:
C18H13ClFN3.HCl
Solubility:
Soluble to 25 mM in water
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
59467-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia.
    Kanto
    Pharmacotherapy, 1985;5:138
  2. Midazolam and other benzodiazepines.
    Olkkola and Ahonen
    Handb.Exp.Pharmacol., 2008;182:335

Product Datasheets

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Reviews for Midazolam hydrochloride

Average Rating: 4.5 (Based on 2 Reviews)

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Midazolam potentiates response of GABA-A receptors even in low concentration
By Anonymous on 08/17/2019
Species: Rat

Midazolam was used to test a response of GABA-A receptors in cerebellar granule cells; the compound has shown a clear potentiatory effect. Figure: evoked EPSCs under control (black) and with 10 microM of Midazolam in perfusion solution (white).


for a study
By Anonymous on 12/01/2017
Species: Human

It worked as planned, never had any issues.


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