Catalog Number: 0941
Chemical Name: 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride
Biological Activity
5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively).
Technical Data
  • M.Wt:
    235.12
  • Formula:
    C8H11ClN4.HCl
  • Solubility:
    Soluble to 50 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    61655-58-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212.
    Hemrick-Luecke and Fuller
    Eur.J.Pharmacol., 1996;311:207
  2. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT2 and 5-HT1C) receptors.
    Conn and Sanders-Bush
    J.Pharmacol.Exp.Ther., 1987;242:552
  3. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
    Jensen et al.
    J.Med.Chem., 2013;56:1211
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MK 212 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
    Authors: Murray Et al.
    Nat Med 2010;16:694
  2. Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis.
    Authors: Yu and Yamaguchi
    J Biomed Sci 2010;103:648
  3. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
    Authors: Yu and Yamaguchi
    J Neurophysiol 2009;102:752

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