MK 212 hydrochloride

Key Product Details

Product Description

MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT_2C over 5-HT_2A (IC₅₀ values are 0.028 and 0.42 μM for human 5-HT_2C and 5-HT_2A receptors expressed in HEK293 cells respectively).

Product Specifications for MK 212 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MK 212 hydrochloride

The following data is based on the product molecular weight 235.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.51 mL	42.53 mL	85.06 mL
2.5 mM	1.70 mL	8.51 mL	17.01 mL
5 mM	0.85 mL	4.25 mL	8.51 mL
25 mM	0.17 mL	0.85 mL	1.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Hemrick-Luecke and Fuller Involvement of 5-HT_2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212. Eur.J.Pharmacol. 1996 PMID: 8891601
• Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
• Conn and Sanders-Bush Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT₂ and 5-HT_1C) receptors. J.Pharmacol.Exp.Ther. 1987 PMID: 3039120

Product Documents for MK 212 hydrochloride