ML 233

Key Product Details

Product Description

ML 233 is a non-peptide apelin receptor agonist (EC₅₀ = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC₅₀ = >79 μM).

Product Specifications for ML 233

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 233

The following data is based on the product molecular weight 359.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.56 mL	27.82 mL	55.64 mL
2.5 mM	1.11 mL	5.56 mL	11.13 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Khan Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program 2011 PMID: 22834038
• Yang Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 2015 PMID: 26143239

Product Documents for ML 233