Home / Two-P Potassium Channels Activators / ML 402

ML 402

Catalog #: 6888 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6888/50
6888/10
ML 402 | CAS No. 298684-44-3 | Two-P Potassium Channels Activators
1 Image
Description: Selective TREK channel activator

Chemical Name: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 402 is a selective TREK channel activator. Selectively activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with no significant effect at K2P4.1 channels (TRAAK).

Technical Data

M.Wt:
295.78
Formula:
C14H14ClNO2S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
298684-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Research

Potent and selective PDE4B inhibitor
Cat # 6313
Inhibitor of HCV RNA-dependent RNA polymerase (RdRP; NS5b); potent hepatitis C virus (HCV) replication inhibitor
Cat # 6974
Proapoptotic; downregulates Bcl-2 and Bcl-XL
Cat # 1964
Reactivator of mutant p53
Cat # 5065
H+,K+-ATPase inhibitor
Cat # 2583
Induces apoptosis in prematurely senescent cells
Cat # 2639
Potent and selective TRPV1 antagonist
Cat # 4330
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active
Cat # 5181
Positive allosteric modulator of GABAB receptors
Cat # 1513
Potent and selective KCC2 inhibitor
Cat # 4719
Potent and selective haspin inhibitor
Cat # 4828
2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Cat # 5389
Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)
Cat # 7087
Potent and selective EZH2/EZH1 inhibitor
Cat # 4904
Potent HDAC6 inhibitor
Cat # 6270
Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
Cat # 4597
Cdk8 inhibitor; enhances IL-10 production
Cat # 6438
Positive allosteric modulator of AMPA receptors
Cat # 5149

Background References

  1. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
    Lolicato et al.
    Nature, 2017;547:364

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ML 402

There are currently no reviews for this product. Be the first to review ML 402 and earn rewards!

Have you used ML 402?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.