ML 402

Key Product Details

Product Description

ML 402 is a selective TREK channel activator. Selectively activates K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) with no significant effect at K_2P4.1 channels (TRAAK).

Product Specifications for ML 402

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 402

The following data is based on the product molecular weight 295.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.38 mL	16.90 mL	33.81 mL
5 mM	0.68 mL	3.38 mL	6.76 mL
10 mM	0.34 mL	1.69 mL	3.38 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lolicato K_2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature 2017 PMID: 28693035

Product Documents for ML 402