Chemical Name: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Biological ActivityML 402 is a selective TREK channel activator. Selectively activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with no significant effect at K2P4.1 channels (TRAAK).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Lolicato et al.
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