Mosapride citrate

Catalog # Availability Size / Price Qty
2844/10
2844/50
Mosapride citrate | CAS No. 112885-42-4 | 5-HT4 Receptor Agonists
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Description: 5-HT4 agonist and 5-HT3 antagonist

Chemical Name: 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide citrate

Purity: ≥99%

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Biological Activity

5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, α1, α2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Technical Data

M.Wt:
614.02
Formula:
C21H25ClFN3O3.C6H8O7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
112885-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. AS-4370, a novel gastrokinetic agent free of DA D2 receptor antagonist properties.
    Yoshida et al.
    Arch.Int.Pharmacodyn.Ther., 1989;300:51
  2. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro.
    Mine et al.
    J.Pharmacol.Exp.Ther., 1997;283:1000
  3. Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals.
    Yoshida et al.
    Arzneim.-Forsch., 1993;43:1078

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