Motilin (human, porcine)
Biological ActivityMotilin (human, porcine) is an endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Motilin and clinical application.
Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.
Coulie et al.
Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors.
Huang et al.
Am.J.Physiol.Gastrointest.Liver Physiol., 2005;288:G23
Citation for Motilin (human, porcine)
The citations listed below are publications that use Tocris products. Selected citations for Motilin (human, porcine) include:
1 Citation: Showing 1 - 1
The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro.
Authors: Broad and Sanger
Br J Pharmacol 2013;168:1859
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Caused contraction of GI smooth muscle 10-300 nM