Catalog Number: 2264
Biological Activity
Endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.
Technical Data
  • M.Wt:
    2699.07
  • Formula:
    C120H188N34O35S
  • Sequence:
    FVPIFTYGELQRMQEKERNKGQ
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    52906-92-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors.
    Huang et al.
    Am.J.Physiol.Gastrointest.Liver Physiol., 2005;288:G23
  2. Motilin and clinical application.
    Itoh
    Peptides, 1997;18:593
  3. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.
    Coulie et al.
    J.Biol.Chem., 2001;276:35518
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Motilin (human, porcine) include:

1 Citations: Showing 1 - 1

  1. The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin.
    Authors: Broad and Sanger
    Br J Pharmacol 2013;168:1859

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