Mouse IFN-gamma  R1/CD119 PE-conjugated Antibody

  • Species Reactivity
  • Specificity
    Detects mouse IFN‑ gamma R1/CD119 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IFN‑ gamma  R1, rhIFN-gamma R2, or rhIL-10 R beta is observed.
  • Source
    Monoclonal Hamster IgG1 Clone # 2E2.4
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Recombinant mouse IFN‑ gamma R1/CD119
    Extracellular domain
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection ofIFN‑ gamma  R1/CD119 in Mouse Splenocytes by FlowCytometry. CD11b+ mouse splenocyteswere stained with Hamster Anti-Mouse IFN‑ gamma  R1/CD119PE‑conjugated Monoclonal Antibody (Catalog # FAB1026P, filledhistogram) or isotype control (open histogram). View our protocol for StainingMembrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IFN-gamma R1/CD119

The high-affinity IFN-gamma  receptor complex is made up of two type I membrane proteins, IFN-gamma  R1 (IFN-gamma  R alpha ) and IFN-gamma  R2 (IFN-gamma  R beta ). Both proteins are members of the type II cytokine receptor family and share approximately 52% overall amino acid (aa) sequence identity. IFN-gamma  R1 is the ligand-binding subunit that is both necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma  R2 is required for IFN-gamma signaling but does not bind IFN-gamma by itself. Mouse IFN-gamma  R1 cDNA encodes a 477 aa residue protein with a 22 aa signal peptide, a 231 aa extracellular domain, a 24 aa transmembrane segment, and a 200 aa intracellular domain. Human and mouse IFN-gamma  R1 share 50% amino acid sequence similarity and bind IFN-gamma in a species-specific manner. IFN-gamma  R1 is constitutively expressed in most cell types. Soluble IFN-gamma  R1 that binds IFN-gamma has been detected in biological fluids. The recombinant soluble IFN-gamma  R1 produced at R&D Systems has been shown to bind IFN-gamma with high affinity and is a potent IFN-gamma antagonist.

  • Long Name:
    Interferon gamma Receptor 1
  • Entrez Gene IDs:
    3459 (Human); 15979 (Mouse)
  • Alternate Names:
    AVP, type 2; CD119 antigen; CD119; FLJ45734; IFN-gamma receptor 1; IFNgammaR1; IFN-gamma-R1; IFNGR; IFNGR1; IFN-gR1; immune interferon receptor 1; interferon gamma receptor 1; interferon-gamma receptor alpha chain; type 2
Related Research Areas
Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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