Mouse IGSF9 Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # FAB9140AFP488

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Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, CyTOF-ready

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 993107
View all IGSF9 Primary Antibodies »

Product Specifications

Specificity

Detects mouse IGSF9 in direct ELISAs.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications for Mouse IGSF9 Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

CyTOF-ready

Optimal dilution of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilution of this antibody should be experimentally determined.

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IGSF9

IGSF9, also known as Dasm1, is an approximately 130 kDa transmembrane protein that plays a role in neuronal synapse maintenance and function (1). Mature mouse Dasm1 consists of a 714 amino acid (aa) extracellular domain (ECD) with 5 Ig-like domains and 2 fibronectin type-3 domains, a 21 aa transmembrane segment, and a 424 aa cytoplasmic domain (2). Within the ECD, mouse Dasm1 shares 90% and 96% aa sequence identity with human and rat Dasm1, respectively. Alternative splicing generates an additional isoform that is truncated following the fifth Ig-like domain. Dasm1 is expressed in the dorsal root and trigeminal ganglia, forebrain, cortex, dentate gyrus, pyramidal cells, Purkinje cells, and hippocampal CA1 interneurons (2-5). It localizes to dendrites, cell bodies, and post-synaptic densities (3, 6). Dasm1 functions as a homophilic adhesion protein that supports the maintenance of inhibitory synapses as well as inhibitory neurotransmission (5, 6).

References

  1. Hansen, M. and P.S. Walmod (2013) Neurochem. Res. 38:1236.
  2. Doudney, K. et al. (2002) Genomics 79:663.
  3. Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13341.
  4. Mishra, A. et al. (2008) Mol. Cell. Biol. 28:2782.
  5. Mishra, A. et al. (2014) J. Neurosci. 34:4187.
  6. Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13346.

Long Name

Immunoglobulin Superfamily, Member 9

Alternate Names

Dasm1, FP18798, IGSF9A, KIAA1355, Nrt1, Protein Turtle Homolog A, TUTLA

Entrez Gene IDs

57549 (Human); 93842 (Mouse); 304982 (Rat)

Gene Symbol

IGSF9

UniProt

Q05BQ1

Additional IGSF9 Products

Product Documents for Mouse IGSF9 Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Mouse IGSF9 Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Integrins and Associated Molecules

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