Protein S (PROS1) is a 70-75 kDa plasma glycoprotein member of the vitamin K dependent family of proteins. It is synthesized by hepatocytes, Sertoli cells, macrophages, vascular smooth muscle cells and endothelium. Protein S is a non-enzymatic cofactor for activated protein C and participates in the degradation of coagulation factors FVa and FVIIIa. It also binds to Axl on smooth muscle, likely initiating mitosis. Protein S circulates free in plasma and, unlike Protein S in human and rat, does not complex with C4BP. Mouse Protein S precursor is 675 amino acids (aa) in length. It contains a signal sequence (aa 1-24), a cleavable prosegment (aa 25-41) and a 634 aa mature region. The mature molecule contains one Gla region (aa 42-87), four EGF-like domains (aa 117-283) and two laminin G-like regions (aa 299-665). Over aa 1-169 of the mature molecule, mouse Protein S shares 80% and 88% aa identity with human and rat Protein S, respectively.
Mouse Protein S/PROS1 Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # FAB4976AFP488
Key Product Details
Species Reactivity
Applications
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Antibody Source
Product Specifications
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Isotype
Applications for Mouse Protein S/PROS1 Alexa Fluor™ Plus 488‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
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Stability & Storage
Background: Protein S/PROS1
Alternate Names
Gene Symbol
UniProt
Additional Protein S/PROS1 Products
Product Documents for Mouse Protein S/PROS1 Alexa Fluor™ Plus 488‑conjugated Antibody
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Product Specific Notices for Mouse Protein S/PROS1 Alexa Fluor™ Plus 488‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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Protocols
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- Cellular Response to Hypoxia Protocols
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