Catalog Number: 1385
Chemical Name: 1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester
Biological Activity
Potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.
Technical Data
  • M.Wt:
    522.56
  • Formula:
    C31H26N2O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    192053-05-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the NIH, US Patent 60/029,855
Background References
  1. New potent and selective human adenosine A3 receptor antagonists.
    Baraldi and Borea
    TiPS, 2000;21:456
  2. Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
    Li et al.
    J.Med.Chem., 1998;41:3186

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