MS049 oxalate salt
Discontinued Product
Chemical Name: N-Methyl-4-(phenylmethoxy)-1-piperidineethanamine oxalate salt
Purity: ≥98%
Biological Activity
Potent and selective PRMT4 and PRMT6 inhibitor (IC50 values are 44 and 63 nM, respectively). Reduces Med12me2a and H3R2me2a levels in HEK293 cells in vitro.To request the negative control for MS049, please fill out the MS049N request form on the SGC website.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Scheer et al.
Nat.Commun., 2019;10:19 -
Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6.
Shen et al.
J.Med.Chem., 2016;59:9124
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