MS049 oxalate salt

Key Product Details

Product Description

Potent and selective PRMT4 and PRMT6 inhibitor (IC₅₀ values are 44 and 63 nM, respectively). Reduces Med12me2a and H3R2me2a levels in HEK293 cells in vitro.

To request the negative control for MS049, please fill out the MS049N request form on the SGC website.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS049 probe summary on the SGC website.

Product Specifications for MS049 oxalate salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MS049 oxalate salt

The following data is based on the product molecular weight 338.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.55 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
• Shen Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6. J.Med.Chem. 2016 PMID: 27584694

Product Documents for MS049 oxalate salt