MSG 606

Name: MSG 606
Brand: Tocris Bioscience
SKU: 5954

Tocris Bioscience | Catalog # 5954

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Product Documents

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Discontinued Product

5954 has been discontinued. View all Melanocortin Receptor Antagonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

View all Melanocortin Receptor Antagonists »

Product Description

MSG 606 is a potent human MC₁ receptor antagonist (IC₅₀ = 17 nM). Also partial agonist at human MC₃ and MC₅ receptors (EC₅₀ values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γMSH analog.

Product Specifications for MSG 606

Molecular Weight

1347.51

Formula

C₆₂H₈₂N₂₀O₁₃S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1416983-77-1

PubChem ID

122177131

InChI Key

QJBNFEXQHBDMQM-VTWSTLNFSA-N

SMILES

NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Juni Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology 2010 PMID: 19996949
Arout Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiol.Behav. 2015 PMID: 25982086
Cai An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry 2013 PMID: 23276279

Product Documents for MSG 606

Certificate of Analysis

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Product Specific Notices for MSG 606

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Nutrition and Appetite

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