MSG 606

Catalog # Availability Size / Price Qty
5954/1
MSG 606
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Description: Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
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Biological Activity

Potent human MC1 receptor antagonist (IC50 = 17 nM). Also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γMSH analog.

Technical Data

M.Wt:
1347.51
Formula:
C62H82N20O13S
Sequence:
XGHFRWCDRFG

(Modifications: X = Butanoic acid, Gly-11 = C-terminal amide, Phe-4 = D-Phe, Trp-6 = D-Trp, carba sulfide bridge between X-1 - Cys-7)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1416983-77-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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