Myelin Basic Protein (87-99)

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Myelin Basic Protein (87-99)
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Description: Major antigenic component implicated in the pathophysiology of multiple sclerosis
Product Details

Biological Activity

Myelin Basic Protein (87-99) is an encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Major antigenic component implicated in the pathophysiology of multiple sclerosis.

Technical Data

Soluble to 2 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats.
    Jones et al.
    J.Neuroimmunol., 1992;37:203
  2. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease.
    Deraos et al.
    J.Med.Chem., 2008;51:7834
  3. Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?
    Hofstetter et al.
    J.Immunol., 2005;22:4598

Product Datasheets

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