Catalog Number: 3399
Biological Activity
Encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Major antigenic component implicated in the pathophysiology of multiple sclerosis.
Technical Data
  • M.Wt:
    1555.8
  • Formula:
    C74H114N20O17
  • Sequence:
    VHFFKNIVTPRTP
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    118506-26-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats.
    Jones et al.
    J.Neuroimmunol., 1992;37:203
  2. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease.
    Deraos et al.
    J.Med.Chem., 2008;51:7834
  3. Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?
    Hofstetter et al.
    J.Immunol., 2005;22:4598

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