Myelin Basic Protein (87-99)

Name: Myelin Basic Protein (87-99)
Brand: Tocris Bioscience
SKU: 3399

Tocris Bioscience | Catalog # 3399

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Product Documents

Major antigenic component implicated in the pathophysiology of multiple sclerosis

Discontinued Product

3399 has been discontinued. View all Neuronal Metabolism Peptides and Compounds products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Major antigenic component implicated in the pathophysiology of multiple sclerosis

View all Neuronal Metabolism Peptides and Compounds »

Product Description

Myelin Basic Protein (87-99) is an encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Major antigenic component implicated in the pathophysiology of multiple sclerosis.

Product Specifications for Myelin Basic Protein (87-99)

Molecular Weight

1555.80

Formula

C₇₄H₁₁₄N₂₀O₁₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

118506-26-6

PubChem ID

25077562

InChI Key

XSSZRUKIAIQNAZ-SAKFXWCOSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Deraos Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease. J.Med.Chem. 2008 PMID: 19053745
Hofstetter Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis? J.Immunol.
Jones The synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 1992 PMID: 1373154

Product Documents for Myelin Basic Protein (87-99)

Certificate of Analysis

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Product Specific Notices for Myelin Basic Protein (87-99)

For research use only

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