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N-Desmethylclozapine

  ( 3 citations )    
Product Datasheet
Catalog Number:1007
Alternate Names:Normethylclozapine, Norclozapine
Chemical Name:8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
Technical Data
  • M.Wt:
    312.8
  • Formula:
    C17H17ClN4
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    6104-71-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for N-Desmethylclozapine include:

3 Citations: Showing 1 - 3
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  1. Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias.
    Authors: Gregory Et al.
    J Biol Chem  2010;285:7459
  2. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation.
    Authors: Magliaro and Saldanha
    Brain Res  2009;1283:14
  3. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
    Authors: Sur Et al.
    Proc Natl Acad Sci U S A  2003;100:13674

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