Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Biological ActivityA major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat.
Fox and Brotchie
Clozapine and methylclozapine are potent 5-HT1C receptor antagonists.
Kuoppam?ki et al.
Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors.
Wong et al.
Citations for N-Desmethylclozapine
The citations listed below are publications that use Tocris products. Selected citations for N-Desmethylclozapine include:
3 Citations: Showing 1 - 3
Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias.
Authors: Gregory Et al.
J Biol Chem 2010;285:7459
Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation.
Authors: Magliaro and Saldanha
Brain Res 2009;1283:14
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
Authors: Sur Et al.
Proc Natl Acad Sci U S A 2003;100:13674
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