N-Desmethylclozapine
Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥99%
Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat.
Fox and Brotchie
Eur.J.Pharmacol., 1996;301:27 -
Clozapine and methylclozapine are potent 5-HT1C receptor antagonists.
Kuoppam?ki et al.
Eur.J.Pharmacol., 1993;245:179 -
Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors.
Wong et al.
Eur.J.Pharmacol., 1996;314:319
Product Datasheets
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Citations for N-Desmethylclozapine
The citations listed below are publications that use Tocris products. Selected citations for N-Desmethylclozapine include:
3 Citations: Showing 1 - 3
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Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias.
Authors: Gregory Et al.
J Biol Chem 2010;285:7459
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Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation.
Authors: Magliaro and Saldanha
Brain Res 2009;1283:14
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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
Authors: Sur Et al.
Proc Natl Acad Sci U S A 2003;100:13674
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