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N106

Catalog #: 5681 Datasheet / COA / SDS

Discontinued Product

5681 has been discontinued.
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N106 | CAS No. 862974-25-2 | Additional Ligase Activators
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Description: Activator of SUMO-activating enzyme, E1 ligase

Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine

Purity: ≥98%

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Biological Activity

N106 is an activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.

Technical Data

M.Wt:
354.38
Formula:
C17H14N4O3S
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
862974-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
    Kho Changwon, Lee Ahyoung, Jeong Dongtak et al.
    Nature Communications

Product Datasheets

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