Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine
Biological ActivityActivator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
Kho Changwon, Lee Ahyoung, Jeong Dongtak et al.
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