Activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro
. Improves ventricular function in a mouse model of heart disease.
Soluble to 20 mM in DMSO
Store at -20°C
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Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
Kho et al.