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NEDD8 Conjugation Initiation Kit

Catalog #: K-800
5 Citations Datasheet / COA / SDS

Discontinued Product

K-800 has been discontinued.
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Citations (5)
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Summary Product Datasheets Background

NEDD8 Conjugation Initiation Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

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Product Datasheet
COA
SDS

Background: NEDD8

NEDD8 (Neural precursor cell-expressed developmentally down-regulated gene 8; also known as Rub1) is a 6-8 kDa member of the ubiquitin family of proteins. It is expressed in striated muscle, and via its C-terminal Gly, forms covalent bonds with cullin family proteins. This conjugation generates ubiquitin ligase activity that regulates cell cycle proteins. Human pro-NEDD8 is 81 amino acids (aa) in length. It contains one ubiquitin-like domain (aa 1-65), and a 4-5 aa C-terminal propeptide that is cleaved to expose a C-terminal Gly residue that is used to generate a Gly-Lys intermolecular bond. Mature human NEDD8 shows 100% aa identity to NEDD8 from both mouse and canine.

Long Name
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
Entrez Gene IDs
4738 (Human); 18002 (Mouse); 25490 (Rat)
Alternate Names
FLJ43224; MGC104393; MGC125896; MGC125897; NEDD8; NEDD-8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; Rub1; Ubiquitin-like protein Nedd8

Citations for NEDD8 Conjugation Initiation Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. STK19 positions TFIIH for cell-free transcription-coupled DNA repair
    Authors: Mevissen, TET;Kümmecke, M;Schmid, EW;Farnung, L;Walter, JC;
    bioRxiv : the preprint server for biology  2024-07-23
  2. Targeting Smurf1 to block PDK1-Akt signaling in KRAS-mutated colorectal cancer
    Authors: Peng, Z;Fang, W;Wu, B;He, M;Li, S;Wei, J;Hao, Y;Jin, L;Liu, M;Zhang, X;Wei, Y;Ge, Y;Wei, Y;Qian, H;Zhang, Y;Jiang, J;Chang, Z;Rao, Y;Zhang, X;Cui, CP;Zhang, L;
    Nature chemical biology  2024-07-22
  3. miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/&beta-catenin signaling pathway
    Authors: Y Huang, Y Xu, S Feng, P He, B Sheng, J Ni
    Experimental & Molecular Medicine, 2021-05-25;0(0):.  2021-05-25
  4. Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction
    Authors: W Zhou, C Xu, G Dong, H Qiao, J Yang, H Liu, L Ding, K Sun, W Zhao
    European Journal of Medicinal Chemistry, 2021-03-12;217(0):113326.  2021-03-12
  5. A metal-based inhibitor of NEDD8-activating enzyme.
    Authors: Zhong H, Yang H, Chan D, Leung C, Wang H, Ma D
    PLoS ONE, 2012-11-19;7(11):e49574.  2012-11-19

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