Neuropeptide SF (mouse, rat)

Name: Neuropeptide SF (mouse, rat)
Brand: Tocris Bioscience
SKU: 3647

Tocris Bioscience | Catalog # 3647

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Product Documents

NPFF1 and NPFF2 agonist

Discontinued Product

3647 has been discontinued. View all Neuropeptide FF/AF Receptor Agonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

NPFF1 and NPFF2 agonist

View all Neuropeptide FF/AF Receptor Agonists »

Product Description

Neuropeptide SF (mouse, rat) is a neuropeptide FF receptor agonist (K_i values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC₅₀ ~ 50 μM).

Product Specifications for Neuropeptide SF (mouse, rat)

Molecular Weight

888.03

Formula

C₄₀H₆₅N₁₃O₁₀

Storage

Store at -20°C

CAS Number

230960-31-3

PubChem ID

90488868

InChI Key

OLOSAWFREOVGQW-CJKZIAQFSA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% acetonitrile / water

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Background References

References are publications that support the biological activity of the product.

Jhamandas Facilitation of spinal mor. analgesia in normal and mor. tolerant animals by neuropeptide SF and related peptides. Peptides 2006 PMID: 16515821
Gouarderes Quantitative autoradiographic distribution of NPFF₁ neuropeptide FF receptor in the rat brain and comparison with NPFF₂ receptor by using [¹²⁵I]YVP and [¹²⁵I]EYF as selective radioligands. Neurosci.
Deval Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 2003 PMID: 12668052

Product Documents for Neuropeptide SF (mouse, rat)

Certificate of Analysis

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Product Specific Notices for Neuropeptide SF (mouse, rat)

For research use only

Related Research Areas

Nutrition and Appetite

Obesity

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