Catalog Number: 3647
Biological Activity
Neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM).
Technical Data
  • M.Wt:
    888.03
  • Formula:
    C40H65N13O10
  • Sequence:
    SLAAPQRF

    (Modifications: Phe-8 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    230960-31-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides.
    Jhamandas et al.
    Peptides, 2006;27:953
  2. Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability.
    Deval et al.
    Neuropharmacology, 2003;44:662
  3. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [125I]EYF as selective radioligands.
    Gouarderes et al.
    Neurosci., 2002;115:349

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