Neuropeptide SF (mouse, rat)

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Neuropeptide SF (mouse, rat)
1 Image
Description: NPFF1 and NPFF2 agonist
Product Details
Supplemental Products

Biological Activity

Neuropeptide SF (mouse, rat) is a neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM).

Technical Data


(Modifications: Phe-8 = C-terminal amide)

Soluble to 1 mg/ml in 20% acetonitrile / water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability.
    Deval et al.
    Neuropharmacology, 2003;44:662
  2. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [125I]EYF as selective radioligands.
    Gouarderes et al.
    Neurosci., 2002;115:349
  3. Facilitation of spinal mor. analgesia in normal and mor. tolerant animals by neuropeptide SF and related peptides.
    Jhamandas et al.
    Peptides, 2006;27:953

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).


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