NIBR 189

Catalog # Availability Size / Price Qty
5203/10
5203/50
NIBR 189 | CAS No. 1599432-08-2 | Orphan 7-TM Receptor Antagonists
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Description: Potent and selective EBI2 (GPR183) receptor antagonist

Chemical Name: (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one

Purity: ≥99%

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Biological Activity

NIBR 189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

Technical Data

M.Wt:
429.31
Formula:
C21H21BrN2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1599432-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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