Catalog Number: 5340
Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Biological Activity
Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.
Technical Data
  • M.Wt:
    400.04
  • Formula:
    C13H10Cl4N2O4
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    203115-63-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
    Aggarwal et al.
    Cancer Res., 2013;73:5497
  2. Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.
    Aggarwal et al.
    Cell Cycle, 2013;12:3329

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