Chemical Name: [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Biological ActivityMitomycin C is an antibiotic and antitumor agent. Covalently binds DNA forming intra- and interstrand crosslinks. Inhibits DNA synthesis. Also used for MEF/STO feeder layer preparation in stem cell culture.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Derivation of mouse embryonic stem cells.
Bryja et al.
Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.
Park et al.
Isolation and structure of a covalent cross-link adduct between mito. C and DNA.
Tomasz et al.
Isolation and structure of an intrastrand cross-link adduct of mito. C and DNA.
Bizanek et al.
Citations for Mitomycin C
The citations listed below are publications that use Tocris products. Selected citations for Mitomycin C include:
5 Citations: Showing 1 - 5
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain DA neurons.
Authors: Kishinevsky Et al.
Nat Commun 2018;9:4345
Molecular basis of MMC enhanced corneal sensory nerve repair after debridement wounding.
Authors: Stepp Et al.
Sci Rep 2018;8:16960
Elucidating Compound Mechanism of Action by Network Perturbation Analysis.
Authors: Woo Et al.
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
Authors: Reinhardt Et al.
PLoS One 2013;8:e59252
Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
Authors: Mayanagi Et al.
J Biol Chem 2008;283:31183
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For studying cell cycle arrest Mitomycin has been used. MEFs have been inactivated with Mitomycin treatment.