Catalog Number: 3258
Alternate Names: Ametycine
Chemical Name: [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Biological Activity
Antibiotic and antitumor agent. Covalently binds DNA forming intra- and interstrand crosslinks. Inhibits DNA synthesis. Also used for MEF/STO feeder layer preparation in stem cell culture.
Technical Data
  • M.Wt:
    334.33
  • Formula:
    C15H18N4O5
  • Solubility:
    Soluble to 5 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    50-07-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA.
    Bizanek et al.
    Biochemistry, 1992;31:3084
  2. Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA.
    Tomasz et al.
    Science, 1987;235:1204
  3. Derivation of mouse embryonic stem cells.
    Bryja et al.
    Nat.Protoc., 2006;1:2082
  4. Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.
    Park et al.
    Nat.Protoc., 2016;11:2154
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mitomycin C include:

2 Citations: Showing 1 - 2
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  1. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt Et al.
    PLoS One 2013;8:e59252
  2. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
    Authors: Mayanagi Et al.
    J Biol Chem 2008;283:31183

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