NSC 697923

Catalog # Availability Size / Price Qty
4858/10
4858/50
NSC 697923 | CAS No. 343351-67-7 | Ubiquitin Conjugating Enzyme (E2) Inhibitors
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Description: Selective UBE2N inhibitor

Chemical Name: 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran

Purity: ≥98%

Product Details
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Biological Activity

Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

Technical Data

M.Wt:
267.26
Formula:
C11H9NO5S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
343351-67-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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