NSC 697923

Key Product Details

Product Description

NSC 697923 is a selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

Product Specifications for NSC 697923

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 697923

The following data is based on the product molecular weight 267.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.71 mL	37.42 mL
5 mM	0.75 mL	3.74 mL	7.48 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cheng A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014 PMID: 24556694
• Pulvino Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 2012 PMID: 22791293

Product Documents for NSC 697923