hh OAC-1 (CAS 300586-90-7): R&D Systems
Catalog Number: 4887
Chemical Name: N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Biological Activity
Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β-catenin signaling.
Technical Data
  • M.Wt:
    237.26
  • Formula:
    C14H11N3O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    300586-90-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of Oct4-activating compounds that enhance reprogramming efficiency.
    Li et al.
    Proc.Natl.Acad.Sci.U S A, 2012;109:20853

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