Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β
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All Tocris products are intended for laboratory research use only.
Identification of Oct4-activating compounds that enhance reprogramming efficiency.
Li et al.
Proc.Natl.Acad.Sci.U S A, 2012;109:20853